CDS22-formula: the original De Simone Formulation, in Ireland
CDS22-formula is the original 8-strain De Simone Formulation, available in 450 billion CFU sachets, 112 billion CFU capsules and infant drops. It is the live bacteria formulation developed by Professor Claudio De Simone, manufactured by EOS2021 S.r.l. and supplied in Ireland by Probiotic.ie, stored refrigerated and dispatched from Dublin.
Every product in this range carries the same eight strains, identified on the current Irish label by their NCIMB deposit codes. Deposit codes are neutral public identifiers, which makes them the most reliable way to confirm what a live bacteria supplement actually contains.
Product status and company independence
CDS22-formula is a food supplement, not a medicine. It is not authorised by the HPRA and it is not intended to diagnose, treat, cure or prevent any disease or health condition. No authorised EU or Irish health claim is made for CDS22-formula or for any of its bacterial strains on this page.
Probiotic.ie is an independent company. We are the authorised Ireland and United Kingdom distributor of CDS22-formula, which is manufactured by EOS2021 S.r.l. We are not affiliated with, endorsed by, sponsored by or connected to any other probiotic manufacturer, brand owner or trademark holder.
Product composition, strain designations and specifications can change. Always check the current pack label before use.
The range at a glance
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Formulation: the original 8-strain De Simone Formulation, strains identified by NCIMB deposit code (NCIMB 30435 to NCIMB 30442)
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Developed by: Professor Claudio De Simone
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Formats: 450 billion CFU sachets ยท 112 billion CFU capsules ยท infant drops
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Manufacturer: EOS2021 S.r.l.
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Irish distributor: Probiotic.ie, authorised Ireland and United Kingdom distributor
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Storage: refrigerated +2ยฐC to +8ยฐC ยท shelf-stable up to 7 days at 25ยฐC per the manufacturer's storage leaflet
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Delivery: tracked across Ireland, dispatched from a temperature-controlled facility in Dublin ยท free over โฌ75
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Regulatory status: food supplement under Irish and EU food law ยท 13.5% VAT applies
Choose your format
Every product in this range is the same De Simone Formulation, carrying the same eight NCIMB-identified strains. They differ by format, pack size and live count per serving.
450bn CFU / sachet
450B Sachets ยท 12 pack
The highest live count per serving in the range. A powder mixed into a cool drink or yogurt.
View the 12 sachet pack โ
450bn CFU / sachet
450B Sachets ยท 36 pack
The same sachets in a larger box, with fewer reorders. Also available on subscription.
View the 36 sachet pack โ
112bn CFU / capsule
112B Capsules
A vegetable capsule for a simple daily routine and for travel. A lower live count per serving than the sachets.
View the capsules โ
Infant format
Infant Drops
Presented in a drop format for babies and young children. Check the pack for the age guidance and dosage.
View the drops โ
All packs, multi-buy bundles and subscription options are listed in the product grid on this page. Speak to your GP, pharmacist or public health nurse before giving any food supplement to a baby or young child.
The eight strains of the De Simone Formulation
Across every format, the formulation is defined by the same eight strains. The current Irish label identifies each one by its NCIMB deposit code, so it can be checked against a public register rather than taken on trust. Total live count per serving varies by product: 450 billion CFU per sachet, 112 billion CFU per capsule.
| Strain |
NCIMB deposit code |
| Streptococcus thermophilus |
NCIMB 30438 |
| Bifidobacterium breve |
NCIMB 30441 |
| Bifidobacterium animalis subsp. lactis |
NCIMB 30435 |
| Bifidobacterium animalis subsp. lactis |
NCIMB 30436 |
| Lactobacillus acidophilus |
NCIMB 30442 |
| Lactobacillus plantarum |
NCIMB 30437 |
| Lactobacillus paracasei |
NCIMB 30439 |
| Lactobacillus helveticus |
NCIMB 30440 |
Strain designations are taken from the current Irish pack label supplied by the manufacturer, EOS2021 S.r.l. Under updated bacterial taxonomy some of these organisms have been reclassified and appear under earlier names in older literature. If you are matching the product to a specific published study, verify by strain code. Always check the current pack label, as specifications can change. See the scientific publications on the De Simone Formulation.
Cold-chain handled, end to end
Every product in this range is a live-culture supplement, so handling matters. We receive it refrigerated from the manufacturer, hold it in dedicated refrigeration at our temperature-controlled facility in Dublin, and dispatch it on a tracked service. Per the manufacturer's storage leaflet it stays shelf-stable at room temperature up to 25ยฐC for up to seven days, which covers normal Irish transit. Refrigerate on arrival. We do not dispatch on Fridays, so nothing sits in a depot over the weekend. See our delivery information.
"As the authorised Ireland and UK distributor, we handle every order under strict cold-chain protocols, from the manufacturer through to your door. That is the part we control, and it is the part that protects the live count you are paying for."
โ Darren Grant, Managing Director, Probiotic.ie
Probiotic.ie is appointed by the manufacturer, EOS2021 S.r.l., as authorised distributor for Ireland and the United Kingdom. Selecting Ireland on the manufacturer's website, cds22.com, directs customers here.
Guides and resources
Background reading is kept separate from this product page. These guides are educational and do not make any claim for the products sold here.
These products are food supplements and are not medicines. They are not intended to diagnose, treat, cure or prevent any disease or health condition. No authorised EU or Irish health claim is made for CDS22-formula or its bacterial strains on this page. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. If you have persistent or worsening symptoms, speak to your GP.
Frequently asked questions
What is CDS22-formula?
CDS22-formula is the original 8-strain De Simone Formulation, a live bacteria food supplement developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Its eight strains are identified on the current Irish label by their NCIMB deposit codes, NCIMB 30435 to NCIMB 30442. The range sold by Probiotic.ie includes 450 billion CFU sachets, 112 billion CFU capsules and infant drops. CDS22-formula is a food supplement, not a medicine.
Which strains are in the De Simone Formulation?
Eight strains, identified by their NCIMB deposit codes: Streptococcus thermophilus NCIMB 30438, Bifidobacterium breve NCIMB 30441, Bifidobacterium animalis subsp. lactis NCIMB 30435 and NCIMB 30436, Lactobacillus acidophilus NCIMB 30442, Lactobacillus plantarum NCIMB 30437, Lactobacillus paracasei NCIMB 30439 and Lactobacillus helveticus NCIMB 30440. Deposit codes identify specific strains and are the most reliable way to confirm what a live bacteria supplement contains. The total live count per serving depends on the product format.
Which format should I choose: sachets, capsules or drops?
All formats contain the same De Simone Formulation and the same eight NCIMB-identified strains, and differ by format and live count per serving. The 450 billion CFU sachets are a powder mixed into a cool drink or yogurt and carry the highest count per serving. The 112 billion CFU vegetable capsules suit a simple daily routine and travel. The infant drops are presented in a drop format for babies and young children. The choice is format preference and the live count you want per serving.
What is the difference between the 450 billion and 112 billion products?
Both contain the same De Simone Formulation with the same eight NCIMB-identified strains. The difference is format and live count per serving. The sachets provide 450 billion CFU per sachet as a powder. The capsules provide 112 billion CFU per vegetable capsule.
What is the difference between the 12 sachet and 36 sachet packs?
Nothing except the number of sachets in the box. Both contain the same De Simone Formulation at 450 billion CFU per sachet. The 36 sachet pack is the larger box and means fewer reorders. Follow the intake directions on the pack.
Who is the authorised Irish distributor of CDS22-formula?
Probiotic.ie is the authorised Ireland and United Kingdom distributor of CDS22-formula, appointed by the manufacturer EOS2021 S.r.l. On the manufacturer's website, cds22.com, selecting Ireland directs customers to Probiotic.ie. Probiotic.ie is an independent company and is not connected to any other probiotic manufacturer or brand owner.
Why does CDS22-formula need cold-chain delivery?
CDS22-formula contains live bacteria. The manufacturer specifies refrigerated storage at +2ยฐC to +8ยฐC to maintain the stated live count through the shelf life. According to the manufacturer's storage leaflet the product remains shelf-stable at room temperature up to 25ยฐC for up to seven days, which covers normal Irish transit. Probiotic.ie dispatches every order from a temperature-controlled facility in Dublin on a tracked service.
How should I store CDS22-formula at home?
Refrigerate at +2ยฐC to +8ยฐC on arrival and keep it refrigerated. Do not freeze. Keep the pack closed and away from direct heat and sunlight. Sachets should be mixed into a cool drink or food rather than a hot one, because heat reduces the live count. Check the best-before date on the pack and keep out of the reach of young children.
Is CDS22-formula a medicine?
No. CDS22-formula is sold in Ireland as a food supplement under Irish and EU food law. It is not a medicine, it is not authorised by the HPRA, and it is not intended to diagnose, treat, cure or prevent any disease or health condition. No prescription is required and no authorised health claim is made for it.
Advisory information (Ireland): Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. Do not exceed the stated recommended daily intake. If you are pregnant or breastfeeding, taking any medication, immunosuppressed, or under medical supervision, consult a doctor or pharmacist before use. Speak to your GP, pharmacist or public health nurse before giving any food supplement to a baby or young child. Keep out of the reach of young children. These products are food supplements and are not medicines. They are sold in Ireland under Irish and EU food law, enforced by the Food Safety Authority of Ireland (FSAI). For health information the HSE is the appropriate reference.
CDS22-formula is manufactured by EOS2021 S.r.l. Probiotic.ie is an independent company, operated by TenX Tech Ltd, and is the authorised distributor of CDS22-formula for Ireland and the United Kingdom. Probiotic.ie is not affiliated with, endorsed by, sponsored by, connected to or distributed by any other probiotic manufacturer, brand owner or trademark holder. Any third-party trademarks referred to elsewhere on this website remain the property of their respective owners.
