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CDS22-Formula | Original De Simone Formulation Probiotic | 450 Billion CFU | 36 Sachets | One Month+ Pack |
€ 73.50 EUR
CDS22-formula Probiotic 450B CFU | Original De Simone Formulation | 12 Sachets
€ 25.95 EUR
CDS22-formula Probiotic 112B CFU | Original De Simone Formulation | 20 Capsules
€ 23.95 EUR
Regular price
€ 24.95 EUR
CDS22-formula Infant Drops – Original De Simone Formulation (2×5 ml Bottles)
€ 17.95 EUR
CDS22-formula Powerful Probiotics
CDS22-formula: the original De Simone Formulation, in Ireland
CDS22-formula is the original 8-strain De Simone Formulation, available in sachets, capsules and infant drops. It is the live bacteria formulation developed by Professor Claudio De Simone, supplied in Ireland by Probiotic.ie, the sole authorised Irish distributor, and dispatched from Dublin.
The same formulation was sold under the VSL#3 brand until 2016 and the Vivomixx brand in the EU and UK until 2025. The identity is carried by the eight strains and their NCIMB deposit codes, not by the brand name.
The De Simone Formulation has had three brand names: VSL#3, then Vivomixx, now CDS22-formula. The formula is the same eight-strain blend.
Looking for Vivomixx or VSL#3 in Ireland?
The 8-strain De Simone Formulation previously sold as Vivomixx (until 2025) and VSL#3 (until 2016) is now supplied in Ireland as CDS22-formula. Same strains, same NCIMB identity, new brand name. For the full background and the clinical-guideline context, see the guides linked below.
The range at a glance
- Formulation: the original 8-strain De Simone Formulation (NCIMB-identified strains)
- Formats: 450 billion CFU sachets · 112 billion CFU capsules · infant drops
- Heritage: sold as VSL#3 until 2016, Vivomixx until 2025, CDS22-formula now
- Distributor: Probiotic.ie, sole authorised Irish distributor (EOS2021-appointed)
- Storage & delivery: stored refrigerated · dispatched next-day from Dublin · free tracked Irish delivery over €75
Choose your format
Every product in this range is the same De Simone Formulation. They differ by format and live count per serving:
450B Sachets
Highest count per serving. A powder you mix into a cool drink or yogurt. Available in multi-packs and on subscription.
View the sachets →112B Capsules
A convenient vegetable capsule for a simple daily routine and for travel. Lower count per serving than the sachets.
View the capsules →Infant Drops
Formulated for babies and young children, in an easy drop format.
View the drops →All packs, multi-buy bundles and subscription options are listed in the product grid on this page.
What the clinical guidelines and research say about the De Simone Formulation
A fully cited Irish reference on what published clinical guidelines and scientific literature say about the De Simone Formulation, the brand-and-formulation history, and how to verify the original by its strain list. Reference-grade, with primary sources.
Read the Irish evidence guide →The 8 strains of the De Simone Formulation
Across every format, the formulation is defined by the same eight strains, identified on the current CDS22-formula label by their NCIMB deposit codes so they can be verified. The total live count per serving varies by product (450 billion per sachet, 112 billion per capsule):
| Strain | NCIMB code |
|---|---|
| Streptococcus thermophilus | NCIMB 30438 |
| Bifidobacterium breve | NCIMB 30441 |
| Bifidobacterium animalis subsp. lactis | NCIMB 30435 |
| Bifidobacterium animalis subsp. lactis | NCIMB 30436 |
| Lactobacillus acidophilus | NCIMB 30442 |
| Lactobacillus plantarum | NCIMB 30437 |
| Lactobacillus paracasei | NCIMB 30439 |
| Lactobacillus helveticus | NCIMB 30440 |
Older clinical literature and the US Visbiome product commonly list the formulation's strains under DSM codes; the current CDS22-formula label uses the NCIMB designations shown above. If you are matching the product to a specific study, verify by strain code. See the scientific publications and clinical studies bibliography.
Storage and delivery in Ireland
Every product in this range is a live-culture supplement, so both correct storage and fast delivery matter. We keep it refrigerated at our temperature-controlled facility in Dublin and dispatch orders the evening before on a tracked next-day service, so most orders arrive within about 24 hours. The capsules and sachets stay stable at room temperature (up to 25°C) for up to a week, so fast tracked transit keeps them well within their safe window; refrigerate on arrival. We do not dispatch on Fridays, so your order never sits in a depot over the weekend. See our delivery information.
"As the sole authorised Irish distributor of CDS22-formula, we store it refrigerated in Dublin and dispatch it fast on a tracked next-day service, so you receive the genuine De Simone Formulation with its live count intact."
— Darren, Probiotic.ie
Guides and resources
Frequently asked questions
What is CDS22-formula?
CDS22-formula is the original 8-strain De Simone Formulation, a live bacteria food supplement developed by Professor Claudio De Simone. It was sold under the VSL#3 brand until 2016 and the Vivomixx brand in the EU and UK until 2025, and is supplied in Ireland today as CDS22-formula. The range includes 450 billion CFU sachets, 112 billion CFU capsules, and infant drops.
Is CDS22-formula the Ireland replacement for Vivomixx?
The 8-strain De Simone Formulation sold in the EU and UK as Vivomixx until 2025 is now supplied in Ireland as CDS22-formula. It carries the same strains, identified by their NCIMB codes. Vivomixx is a registered trademark of Mendes SA; CDS22-formula is not affiliated with it. Identity is best confirmed by the strain list rather than the brand name.
Which CDS22-formula should I choose: sachets, capsules or drops?
All are the same De Simone Formulation; they differ by format and live count per serving. The 450 billion CFU sachets are a powder you mix into a cool drink or yogurt and have the highest count per serving. The 112 billion CFU capsules suit a simple daily routine. The infant drops are formulated for babies and young children. The choice is format preference and the count you want per serving.
What is the difference between the 450 billion and 112 billion versions?
Both are the same 8-strain De Simone Formulation with the same NCIMB strains. The difference is the live count per serving and the format: the sachets provide 450 billion CFU per sachet as a powder, while the capsules provide 112 billion CFU per vegetable capsule.
Who is the official Irish distributor of CDS22-formula?
Probiotic.ie is the sole authorised Irish distributor of CDS22-formula, appointed by the manufacturer EOS2021 S.r.l. On the manufacturer's website, cds22.com, selecting Ireland directs customers to Probiotic.ie as the authorised distributor. Buying from the authorised distributor is how you confirm you are receiving the genuine De Simone Formulation, stored refrigerated and shipped from Dublin.
Which strains are in the De Simone Formulation?
The current CDS22-formula label lists eight strains by their NCIMB deposit codes: Streptococcus thermophilus NCIMB 30438, Bifidobacterium breve NCIMB 30441, Bifidobacterium animalis subsp. lactis NCIMB 30435 and NCIMB 30436, Lactobacillus acidophilus NCIMB 30442, Lactobacillus plantarum NCIMB 30437, Lactobacillus paracasei NCIMB 30439, and Lactobacillus helveticus NCIMB 30440. The total CFU per serving depends on the product format.
How is CDS22-formula stored and delivered in Ireland?
CDS22-formula is a live-culture supplement. We keep it refrigerated at our temperature-controlled facility in Dublin and dispatch orders the evening before on a tracked next-day service, so most orders arrive within about 24 hours. The capsules and sachets stay stable at room temperature (up to 25°C) for up to a week, so fast tracked delivery keeps them within their safe window; refrigerate on arrival. We do not dispatch on Fridays, so nothing sits in a depot over the weekend. Delivery is tracked across Ireland and free over €75.
Is CDS22-formula a medicine?
No. CDS22-formula is sold legally in Ireland as a food supplement. It is not a medicine and is not intended to diagnose, treat, cure or prevent any disease. No prescription is required.
VSL#3® is a registered trademark of VSL Pharmaceuticals Inc. and Actial S.r.l. Vivomixx® is a registered trademark of Mendes SA. Visbiome® is a registered trademark of ExeGi Pharma. CDS22-formula is manufactured by EOS2021 S.r.l. and is not affiliated with, endorsed by, or distributed by the VSL#3, Vivomixx or Visbiome trademark holders. Historical brand names are used for identification and factual continuity only.