CDS22-formula Probiotic 112B CFU | Original De Simone Formulation | 20 Capsules
CDS22-formula Probiotic 112B CFU | Original De Simone Formulation | 20 Capsules
CDS22-formula is the original 8-strain De Simone Formulation, supplied as 20 vegetable capsules, with 112 billion live bacteria (CFU) in every capsule.
The formulation was developed by Professor Claudio De Simone and is manufactured by EOS2021 S.r.l. Its identity is carried by the eight strains and their NCIMB deposit codes, which are neutral public identifiers and the most reliable way to confirm what a live bacteria supplement contains.
At a glance
- Format: 20 vegetable (HPMC) capsules per pack
- Live bacteria: 112 billion CFU per capsule, across 8 strains
- Strain identity: 8 strains with NCIMB deposit codes (full list below)
- Formulation: the original De Simone Formulation, developed by Professor Claudio De Simone
- Manufacturer: EOS2021 S.r.l.
- Suitable for: vegetarians · gluten-free · no preservatives or synthetic sweeteners
- Storage: refrigerate +2°C to +8°C (shelf-stable to 25°C for up to 7 days per the manufacturer's storage leaflet)
- Price & delivery: €23.95 inc. Irish VAT at 13.5% · stored refrigerated in Dublin · free tracked Irish delivery over €75
Strain composition (per capsule)
| Strain | NCIMB code | CFU per capsule |
|---|---|---|
| Streptococcus thermophilus | NCIMB 30438 | 58 billion |
| Lactobacillus acidophilus | NCIMB 30442 | 9 billion |
| Lactobacillus plantarum | NCIMB 30437 | 9 billion |
| Lactobacillus paracasei | NCIMB 30439 | 9 billion |
| Lactobacillus helveticus | NCIMB 30440 | 9 billion |
| Bifidobacterium breve | NCIMB 30441 | 6 billion |
| Bifidobacterium animalis subsp. lactis | NCIMB 30435 | 6 billion |
| Bifidobacterium animalis subsp. lactis | NCIMB 30436 | 6 billion |
| Total live bacteria per capsule | 112 billion | |
Full ingredients: mixture of lactic ferments (the 8 strains listed above); bulking agent: microcrystalline cellulose; capsule shell: hydroxypropylmethylcellulose (vegetable); anti-caking agents: fatty acids, magnesium salts of fatty acids. Gluten-free. Contains no preservatives or synthetic sweeteners. Older clinical literature lists these organisms under DSM codes and, under updated taxonomy, some appear under earlier species names. The current Irish label uses the NCIMB designations above. Product composition and specifications can change — always check the current pack label before use.
Key features
- 112 billion CFU per capsule — 8 strains, each identified by its NCIMB deposit code
- The original De Simone Formulation, developed by Professor Claudio De Simone
- Vegetable HPMC capsule — suitable for vegetarians; gluten-free
- No preservatives and no synthetic sweeteners
- Held refrigerated at our temperature-controlled Dublin facility, dispatched on a tracked service (no Friday dispatch)
- Sole exclusive distributor of CDS22-formula for Ireland and the UK, under written agreement with the manufacturer, EOS2021 S.r.l.
Storage and delivery in Ireland
This is a live-culture product, so correct storage matters. Per the manufacturer's storage leaflet the capsules are shelf-stable at room temperature up to 25°C for up to seven days, which comfortably covers a tracked Irish delivery, so no ice packs are needed.
We hold stock refrigerated at +2°C to +8°C at our temperature-controlled facility in Dublin, from receipt through to dispatch, and send every order on a tracked service. We do not dispatch on Fridays, so nothing sits in a depot over the weekend. Refrigerate on arrival to maintain the live count through to the best-before date. Delivery is tracked across Ireland and free over €75, and because orders ship from Dublin no customs charges apply. See our delivery information.
How to take
Adults: 1 to 4 capsules daily, preferably before meals, with water. Do not exceed the recommended daily dose. Keep refrigerated. Dosing for children is set out in the manufacturer Patient Information Sheet; for babies and young children see CDS22-formula Infant Drops.
Choosing the right format
The 112 billion capsule is the everyday format. If you want a higher count per serving, a non-capsule option, or you are buying for a young child, these may suit better:
- CDS22-formula 450 billion sachets, 12 pack — higher count per serving, powder format
- CDS22-formula 450 billion sachets, 36 pack — the larger box, fewer reorders
- CDS22-formula Infant Drops — for babies and young children
- All CDS22-formula products — full range
Background and evidence: scientific publications on the De Simone Formulation · Clinical Probiotics Ireland: strains, CFU & how to choose · all guides
Frequently asked questions
What is CDS22-formula?
CDS22-formula is a high-count, multi-strain live bacteria food supplement. It is the original 8-strain De Simone Formulation, developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Each vegetable capsule contains 112 billion CFU across 8 strains, identified on the Irish label by their NCIMB deposit codes. A pack contains 20 capsules.
What is the De Simone Formulation?
The De Simone Formulation is an 8-strain live bacteria mixture developed by Professor Claudio De Simone in the early 1990s. Its strains are identified by NCIMB deposit codes, which are neutral public identifiers, so the composition can be checked against a public register rather than taken on trust. It is manufactured by EOS2021 S.r.l. and supplied in Ireland as CDS22-formula.
Which strains are in CDS22-formula, and at what CFU?
Each capsule contains 112 billion CFU: Streptococcus thermophilus NCIMB 30438 (58 billion), Lactobacillus acidophilus NCIMB 30442 (9 billion), Lactobacillus plantarum NCIMB 30437 (9 billion), Lactobacillus paracasei NCIMB 30439 (9 billion), Lactobacillus helveticus NCIMB 30440 (9 billion), Bifidobacterium breve NCIMB 30441 (6 billion), and Bifidobacterium animalis subsp. lactis NCIMB 30435 and NCIMB 30436 (6 billion each).
Should I choose the capsules or the sachets?
Both contain the same De Simone Formulation with the same eight NCIMB-identified strains. The difference is format and live count per serving. The capsules provide 112 billion CFU per vegetable capsule and suit a simple daily routine and travel. The sachets provide 450 billion CFU per sachet as a powder mixed into a cool drink or yogurt. The choice is format preference and the count you want per serving.
Is CDS22-formula suitable for vegetarians?
Yes. The capsule shell is hydroxypropylmethylcellulose (HPMC), a vegetable capsule, so the product is suitable for vegetarians. It is also gluten-free and contains no preservatives or synthetic sweeteners. Always check the current pack label, as specifications can change.
Why does CDS22-formula need to be kept refrigerated?
CDS22-formula contains live bacteria. The manufacturer specifies refrigerated storage at +2°C to +8°C to maintain the stated live count through the product's shelf life. Per the manufacturer's storage leaflet it stays shelf-stable at room temperature up to 25°C for up to seven days, which comfortably covers a tracked Irish delivery. Refrigerate it when it arrives.
How many capsules are in a pack and how do I take them?
A pack contains 20 vegetable capsules. The manufacturer direction for adults is 1 to 4 capsules daily, preferably before meals, taken with water. Do not exceed the recommended daily dose. Keep refrigerated. Dosing for children is set out in the manufacturer's Patient Information Sheet.
How is CDS22-formula delivered in Ireland?
Probiotic.ie holds stock refrigerated at +2°C to +8°C at a temperature-controlled facility in Dublin and dispatches every order on a tracked service. Per the manufacturer's storage leaflet the capsules are shelf-stable at room temperature up to 25°C for up to seven days, which covers normal Irish transit. We do not dispatch on Fridays, so nothing sits in a depot over the weekend. Delivery is tracked across Ireland and free over €75. Because orders ship from Dublin, no customs charges apply to Irish deliveries.
Who is the authorised Irish distributor of CDS22-formula?
Probiotic.ie is the sole exclusive distributor of CDS22-formula for Ireland and the United Kingdom, appointed under written agreement with the manufacturer, EOS2021 S.r.l. Selecting Ireland on the manufacturer's website, cds22.com, directs customers to Probiotic.ie. Probiotic.ie is an independent company and is not connected to any other probiotic manufacturer or brand owner.
Is CDS22-formula a medicine?
No. CDS22-formula is sold legally in Ireland as a food supplement under FSAI guidelines. It is not a medicine, it is not authorised by the HPRA, and it is not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, breastfeeding, taking medication or under medical supervision, consult a doctor or pharmacist before use.
Product details: CDS22-formula · 20 vegetable (HPMC) capsules · 112 billion CFU per capsule · 8 strains with NCIMB deposit codes · the original De Simone Formulation · manufactured by EOS2021 S.r.l. · €23.95 inc. Irish VAT at 13.5%.
CDS22-formula is manufactured by EOS2021 S.r.l. Probiotic.ie is an independent company, operated by TenX Tech Ltd, and is the sole exclusive distributor of CDS22-formula for Ireland and the United Kingdom. Probiotic.ie is not affiliated with, endorsed by, sponsored by, connected to or distributed by any other probiotic manufacturer, brand owner or trademark holder. Any third-party trademarks referred to elsewhere on this website remain the property of their respective owners.