CDS22-formula Probiotic 450B CFU | Original De Simone Formulation | 12 Sachets
CDS22-formula Probiotic 450B CFU | Original De Simone Formulation | 12 Sachets
CDS22-formula 450B — Original De Simone Formulation (12 Sachets)
One of the highest-potency probiotic formulations available, at 450 billion live cultures (CFU) per sachet across 8 strains. CDS22-formula is the original De Simone Formulation, developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Stored refrigerated at our temperature-controlled facility in Dublin and dispatched on a tracked service across Ireland.
- Original 8-strain De Simone Formulation, 450 billion live cultures (CFU) per sachet
- 8 strains identified by NCIMB deposit code, so they can be checked against a public register
- Documented in 200+ scientific publications, including 80+ clinical studies
- Stored refrigerated (+2–8°C) · shelf-stable up to 7 days at 25°C per the manufacturer's storage leaflet
- Food supplement under FSAI guidelines — not a medicine. Gluten-free. Suitable from age 3
CDS22-formula definition: CDS22-formula is the original 8-strain, 450 billion CFU probiotic mixture developed by Professor Claudio De Simone, known as the De Simone Formulation, manufactured by EOS2021 S.r.l. and supplied in Ireland by Probiotic.ie.
One of the most documented probiotic formulations by name
Of the probiotic formulations available to Irish consumers, the De Simone Formulation has one of the most extensive evidence bases in the scientific literature. It is referenced in over 200 scientific publications, of which more than 80 are clinical studies.
The AGA 2024 guideline (Barnes et al., Gastroenterology 2024;166(1):59-85, PMID 38128971) names the De Simone Formulation. The formulation has also been studied in registered clinical trials including NCT01765439, and more recent trials name it directly, for example Rousseau et al. (J Acquir Immune Defic Syndr, 2022), which studied the "De Simone Formulation Probiotic."
The publications referenced above describe the De Simone Formulation as studied in the scientific literature. They are not a claim that this food supplement produces any effect, and no authorised EU or Irish health claim is made for CDS22-formula or its bacterial strains on this page. This product is a food supplement, not a medicine.
The 8 strains in CDS22-formula
Each sachet delivers 450 billion live cultures across 8 strains, identified by their NCIMB deposit codes so they can be verified against the published literature:
| Strain | NCIMB code | Per sachet |
|---|---|---|
| Streptococcus thermophilus | NCIMB 30438 | 226 billion |
| Bifidobacterium breve | NCIMB 30441 | 24 billion |
| Bifidobacterium animalis subsp. lactis | NCIMB 30435 | 24 billion |
| Bifidobacterium animalis subsp. lactis | NCIMB 30436 | 24 billion |
| Lactobacillus acidophilus | NCIMB 30442 | 38 billion |
| Lactobacillus plantarum | NCIMB 30437 | 38 billion |
| Lactobacillus paracasei | NCIMB 30439 | 38 billion |
| Lactobacillus helveticus | NCIMB 30440 | 38 billion |
| Total live cultures per sachet | 450 billion |
Older clinical literature lists these organisms under DSM codes (e.g. DSM 24731–24737). Under updated bacterial taxonomy some also appear under earlier species names. The current Irish CDS22-formula label uses the NCIMB designations above. If you are matching the product to a specific published study, verify by strain code rather than by name.
To compare strains and CFU across the clinical probiotics available in Ireland, see Clinical Probiotics Ireland: Strains, CFU & How to Choose.
Sachets or capsules?
| Format | CFU | Typical use |
|---|---|---|
| 450B Sachets (this product) | 450 billion / sachet | High-potency daily use; mix into a cool drink, yogurt or juice |
| 112B Capsules | 112 billion / capsule | Convenient daily maintenance in capsule form |
Both formats contain the De Simone Formulation. The choice is potency preference and convenience. Buying for a month or more? The 36-sachet pack qualifies for free tracked Irish delivery over €75.
How we handle a refrigerated probiotic in Ireland
A common question: will a refrigerated product survive delivery? CDS22-formula is shelf-stable at room temperature (up to 25°C) for up to 7 days, per the manufacturer's storage leaflet, so a normal tracked Irish delivery is comfortably inside that window.
- Stored refrigerated at +2–8°C in our temperature-controlled facility in Dublin, from receipt to dispatch.
- Tracked delivery across Ireland, free on orders over €75.
- No Friday dispatch, so nothing sits in a depot over the weekend.
- Refrigerate on arrival to maintain the live count through to the best-before date.
Full delivery and storage information
Why buy from Probiotic.ie
- Sole exclusive distributor of CDS22-formula for Ireland and the United Kingdom, appointed under written agreement with the manufacturer, EOS2021 S.r.l. Selecting Ireland on cds22.com directs customers here.
- Refrigerated storage from receipt to dispatch at our temperature-controlled Dublin facility, so the live count on the label is the count you receive.
- Irish-owned specialist since 2019, with real human support.
Product details
Food supplement with 450 billion live cultures per sachet. Format: 12 sachets of 4.4g, 18-month shelf life from manufacture when stored refrigerated. Manufacturer: EOS2021 S.r.l. GTIN/EAN: 8055039380144.
Ingredients
Maltose, mixture of lactic ferments (Streptococcus thermophilus NCIMB 30438, Bifidobacterium breve NCIMB 30441, Bifidobacterium animalis subsp. lactis NCIMB 30435, Bifidobacterium animalis subsp. lactis NCIMB 30436, Lactobacillus acidophilus NCIMB 30442, Lactobacillus plantarum NCIMB 30437, Lactobacillus paracasei NCIMB 30439, Lactobacillus helveticus NCIMB 30440).
Gluten-free. No preservatives or synthetic sweeteners. The live cell count refers to the product correctly stored in intact packaging at refrigerated temperature (+2–8°C) until the best-before date. Product composition and specifications can change — always check the current pack label before use.
How to use
- Adults and children 7+: 1–2 sachets per day.
- Children 3–6 years: up to ½ sachet per day.
- Open and mix into a cool, non-fizzy drink, yogurt or fruit juice; consume immediately. Do not add to hot liquids.
- Do not exceed the recommended daily dose.
Storage
- Store in the refrigerator (+2–8°C) to maintain the live cultures until the best-before date.
- Can be kept at room temperature (up to 25°C) for up to one week.
- Avoid temperatures above 25°C. Do not freeze.
If you are pregnant, breastfeeding, taking medication or under medical supervision, consult your doctor or pharmacist before use. CDS22-formula can be taken alongside antibiotics; taking it a few hours apart from the antibiotic dose is commonly advised. Anyone immunocompromised or seriously unwell should speak to a doctor first. For a young child, check with your GP or public health nurse before use.
Important: CDS22-formula is a food supplement, not a medicine. It is not intended to diagnose, treat, cure or prevent any disease or health condition. No authorised EU or Irish health claim is made for CDS22-formula or its bacterial strains on this page. The information here is for general information only and does not replace advice from a doctor, pharmacist or other qualified health professional. Food supplements in Ireland are regulated by the FSAI; for health information the HSE is the appropriate reference. Probiotic.ie is an independent company, operated by TenX Tech Ltd, and is not affiliated with, endorsed by, sponsored by or connected to any other probiotic manufacturer, brand owner or trademark holder.
Frequently asked questions
What is CDS22-formula?
CDS22-formula is the original 8-strain De Simone Formulation, a live bacteria food supplement developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Each sachet provides 450 billion live cultures (CFU) across eight strains, each identified on the Irish label by its NCIMB deposit code. It is sold in Ireland as a food supplement, not a medicine.
How many strains and how much CFU does CDS22-formula contain?
Each sachet contains 8 bacterial strains delivering 450 billion live cultures (CFU): Streptococcus thermophilus NCIMB 30438 (226 billion), Bifidobacterium breve NCIMB 30441 (24 billion), Bifidobacterium animalis subsp. lactis NCIMB 30435 (24 billion), Bifidobacterium animalis subsp. lactis NCIMB 30436 (24 billion), Lactobacillus acidophilus NCIMB 30442 (38 billion), Lactobacillus plantarum NCIMB 30437 (38 billion), Lactobacillus paracasei NCIMB 30439 (38 billion), and Lactobacillus helveticus NCIMB 30440 (38 billion). The capsule format delivers 112 billion CFU per capsule.
Does CDS22-formula need to be refrigerated?
Yes. CDS22-formula is a refrigerated product and should be stored at +2–8°C to maintain the live cultures, with an 18-month shelf life from manufacture when kept refrigerated. It can be kept at room temperature (up to 25°C) for up to one week. Probiotic.ie stores it refrigerated at a temperature-controlled facility in Dublin and dispatches on a tracked service across Ireland.
Will CDS22-formula still be good when it arrives?
Yes. Per the manufacturer's storage leaflet, CDS22-formula is shelf-stable at room temperature up to 25°C for up to seven days, which comfortably covers a tracked Irish delivery. Probiotic.ie holds stock refrigerated in Dublin and does not dispatch on Fridays, so orders do not sit in a depot over the weekend. Refrigerate the product on arrival.
Is CDS22-formula a medicine, and is it legal in Ireland?
CDS22-formula is sold legally in Ireland as a food supplement under FSAI guidelines. It is not a medicine, it is not authorised by the HPRA, and it is not intended to diagnose, treat, cure or prevent any disease. No prescription is required.
How do I take CDS22-formula?
Adults and children aged 7+ take 1–2 sachets per day; children aged 3–6 take up to ½ sachet per day. Mix the contents into a cool, non-fizzy drink, yogurt or fruit juice and consume immediately. Do not add to hot liquids. Do not exceed the recommended daily dose.
Who is the authorised Irish distributor of CDS22-formula?
Probiotic.ie is the sole exclusive distributor of CDS22-formula for Ireland and the United Kingdom, appointed under written agreement with the manufacturer, EOS2021 S.r.l. Selecting Ireland on the manufacturer's website, cds22.com, directs customers to Probiotic.ie. Probiotic.ie is an independent company and is not connected to any other probiotic manufacturer or brand owner.
Download the Patient Information Sheet · See the full CDS22-formula range