{"product_id":"cds22-formula-probiotic-450-billion-12-sachets","title":"CDS22-formula Probiotic 450B CFU | Original De Simone Formulation | 12 Sachets","description":"\u003cstyle\u003e\n  .cds-wrap{max-width:900px;margin:0 auto;font-family:'Helvetica Neue',Arial,sans-serif;color:#1a1f2e;line-height:1.6}\n  .cds-wrap h2{font-size:22px;color:#1a1f2e;margin:26px 0 10px;line-height:1.25}\n  .cds-wrap h3{font-size:17px;color:#1a1f2e;margin:18px 0 8px}\n  .cds-wrap p{margin:10px 0}\n  .cds-wrap ul{margin:8px 0 14px 20px}\n  .cds-wrap li{margin:6px 0}\n  .cds-lead{font-size:18px;color:#374151}\n  .cds-box{border:1px solid #e5e7eb;border-radius:12px;padding:16px 18px;background:#f9fafb;margin:16px 0}\n  .cds-teal{border:1px solid #99f6e4;background:#f0fdfa;border-radius:12px;padding:16px 18px;margin:16px 0}\n  .cds-teal .lbl{font-size:12px;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:#0d9488;margin-bottom:6px}\n  .cds-blue{border-left:4px solid #0284c7;background:#f0f9ff;border-radius:0 10px 10px 0;padding:14px 16px;margin:16px 0}\n  .cds-blue .lbl{font-size:12px;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:#0284c7;margin-bottom:6px}\n  .cds-amber{border-left:4px solid #b45309;background:#fffbeb;border-radius:0 10px 10px 0;padding:14px 16px;margin:16px 0}\n  .cds-amber .lbl{font-size:12px;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:#b45309;margin-bottom:6px}\n  .cds-facts{display:grid;grid-template-columns:repeat(2,1fr);gap:10px;margin:16px 0}\n  .cds-fact{border:1px solid #e5e7eb;border-radius:10px;padding:12px;background:#fff}\n  .cds-fact .n{font-size:20px;font-weight:700;color:#0d9488;display:block}\n  .cds-fact .l{font-size:12px;color:#6b7280}\n  .cds-tw{overflow-x:auto;border:1px solid #eaeaea;border-radius:12px;margin:14px 0}\n  table.cds-t{width:100%;border-collapse:collapse;min-width:560px;font-size:14px}\n  table.cds-t th,table.cds-t td{border-bottom:1px solid #eee;padding:9px 11px;text-align:left;vertical-align:top}\n  table.cds-t th{background:#1a1f2e;color:#fff;font-weight:600}\n  .cds-links a{color:#0d9488;font-weight:600}\n  .cds-note{font-size:13px;color:#6b7280}\n  .cds-faq h3{margin:14px 0 4px}\n  @media(max-width:560px){.cds-facts{grid-template-columns:1fr}}\n\u003c\/style\u003e\n\n\u003cdiv class=\"cds-wrap\"\u003e\n\n  \u003ch2 style=\"color:#16a34a;\"\u003eCDS22-formula 450B — Original De Simone Formulation (12 Sachets)\u003c\/h2\u003e\n  \u003cp class=\"cds-lead\"\u003eOne of the highest-potency probiotic formulations available, at 450 billion live cultures (CFU) per sachet across 8 strains. CDS22-formula is the original De Simone Formulation, developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Stored refrigerated at our temperature-controlled facility in Dublin and dispatched on a tracked service across Ireland.\u003c\/p\u003e\n\n  \u003cdiv class=\"cds-teal\"\u003e\n    \u003cdiv class=\"lbl\"\u003eAt a Glance\u003c\/div\u003e\n    \u003cul style=\"margin:0;padding-left:18px;\"\u003e\n      \u003cli\u003eOriginal 8-strain De Simone Formulation, 450 billion live cultures (CFU) per sachet\u003c\/li\u003e\n      \u003cli\u003e8 strains identified by NCIMB deposit code, so they can be checked against a public register\u003c\/li\u003e\n      \u003cli\u003eDocumented in 200+ scientific publications, including 80+ clinical studies\u003c\/li\u003e\n      \u003cli\u003eStored refrigerated (+2–8°C) · shelf-stable up to 7 days at 25°C per the manufacturer's storage leaflet\u003c\/li\u003e\n      \u003cli\u003eFood supplement under FSAI guidelines — not a medicine. Gluten-free. Suitable from age 3\u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/div\u003e\n\n  \u003cp\u003e\u003cstrong\u003eCDS22-formula definition:\u003c\/strong\u003e CDS22-formula is the original 8-strain, 450 billion CFU probiotic mixture developed by Professor Claudio De Simone, known as the De Simone Formulation, manufactured by EOS2021 S.r.l. and supplied in Ireland by Probiotic.ie.\u003c\/p\u003e\n\n  \u003ch2\u003eOne of the most documented probiotic formulations by name\u003c\/h2\u003e\n  \u003cp\u003eOf the probiotic formulations available to Irish consumers, the De Simone Formulation has one of the most extensive evidence bases in the scientific literature. It is referenced in over \u003ca href=\"https:\/\/probiotic.ie\/pages\/cds22-de-simone-formulation-scientific-studies\" target=\"_blank\" rel=\"noopener\"\u003e200 scientific publications\u003c\/a\u003e, of which more than 80 are clinical studies.\u003c\/p\u003e\n  \u003cp\u003eThe \u003cstrong\u003eAGA 2024 guideline\u003c\/strong\u003e (Barnes et al., \u003cem\u003eGastroenterology\u003c\/em\u003e 2024;166(1):59-85, PMID 38128971) names the De Simone Formulation. The formulation has also been studied in registered clinical trials including \u003ca href=\"https:\/\/clinicaltrials.gov\/study\/NCT01765439\" target=\"_blank\" rel=\"noopener\"\u003eNCT01765439\u003c\/a\u003e, and more recent trials name it directly, for example Rousseau et al. (\u003cem\u003eJ Acquir Immune Defic Syndr\u003c\/em\u003e, 2022), which studied the \"De Simone Formulation Probiotic.\"\u003c\/p\u003e\n\n  \u003cdiv class=\"cds-amber\"\u003e\n    \u003cdiv class=\"lbl\"\u003eResearch context — not product claims\u003c\/div\u003e\n    \u003cp style=\"margin:0;\"\u003eThe publications referenced above describe the De Simone Formulation as studied in the scientific literature. They are not a claim that this food supplement produces any effect, and no authorised EU or Irish health claim is made for CDS22-formula or its bacterial strains on this page. This product is a food supplement, not a medicine.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv class=\"cds-facts\"\u003e\n    \u003cdiv class=\"cds-fact\"\u003e\n\u003cspan class=\"n\"\u003e450B\u003c\/span\u003e\u003cspan class=\"l\"\u003eCFU per sachet\u003c\/span\u003e\n\u003c\/div\u003e\n    \u003cdiv class=\"cds-fact\"\u003e\n\u003cspan class=\"n\"\u003e8\u003c\/span\u003e\u003cspan class=\"l\"\u003ebacterial strains (NCIMB)\u003c\/span\u003e\n\u003c\/div\u003e\n    \u003cdiv class=\"cds-fact\"\u003e\n\u003cspan class=\"n\"\u003e200+\u003c\/span\u003e\u003cspan class=\"l\"\u003escientific publications\u003c\/span\u003e\n\u003c\/div\u003e\n    \u003cdiv class=\"cds-fact\"\u003e\n\u003cspan class=\"n\"\u003e+2–8°C\u003c\/span\u003e\u003cspan class=\"l\"\u003erefrigerated storage\u003c\/span\u003e\n\u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eThe 8 strains in CDS22-formula\u003c\/h2\u003e\n  \u003cp\u003eEach sachet delivers 450 billion live cultures across 8 strains, identified by their NCIMB deposit codes so they can be verified against the published literature:\u003c\/p\u003e\n  \u003cdiv class=\"cds-tw\"\u003e\n    \u003ctable class=\"cds-t\"\u003e\n      \u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eStrain\u003c\/th\u003e\n\u003cth\u003eNCIMB code\u003c\/th\u003e\n\u003cth\u003ePer sachet\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n      \u003ctbody\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cem\u003eStreptococcus thermophilus\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30438\u003c\/td\u003e\n\u003ctd\u003e226 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cem\u003eBifidobacterium breve\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30441\u003c\/td\u003e\n\u003ctd\u003e24 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eBifidobacterium animalis\u003c\/em\u003e subsp. \u003cem\u003elactis\u003c\/em\u003e\n\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30435\u003c\/td\u003e\n\u003ctd\u003e24 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\n\u003cem\u003eBifidobacterium animalis\u003c\/em\u003e subsp. \u003cem\u003elactis\u003c\/em\u003e\n\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30436\u003c\/td\u003e\n\u003ctd\u003e24 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cem\u003eLactobacillus acidophilus\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30442\u003c\/td\u003e\n\u003ctd\u003e38 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cem\u003eLactobacillus plantarum\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30437\u003c\/td\u003e\n\u003ctd\u003e38 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cem\u003eLactobacillus paracasei\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30439\u003c\/td\u003e\n\u003ctd\u003e38 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cem\u003eLactobacillus helveticus\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd\u003eNCIMB 30440\u003c\/td\u003e\n\u003ctd\u003e38 billion\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTotal live cultures per sachet\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003e450 billion\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003c\/tbody\u003e\n    \u003c\/table\u003e\n  \u003c\/div\u003e\n  \u003cp class=\"cds-note\"\u003eOlder clinical literature lists these organisms under DSM codes (e.g. DSM 24731–24737). Under updated bacterial taxonomy some also appear under earlier species names. The current Irish CDS22-formula label uses the NCIMB designations above. If you are matching the product to a specific published study, verify by strain code rather than by name.\u003c\/p\u003e\n\n  \u003cdiv class=\"cds-blue\"\u003e\n    \u003cdiv class=\"lbl\"\u003eCompare across the probiotic range\u003c\/div\u003e\n    \u003cp style=\"margin:0;\" class=\"cds-links\"\u003eTo compare strains and CFU across the clinical probiotics available in Ireland, see \u003ca href=\"https:\/\/probiotic.ie\/blogs\/blog\/clinical-probiotics-ireland\" target=\"_blank\" rel=\"noopener\"\u003eClinical Probiotics Ireland: Strains, CFU \u0026amp; How to Choose\u003c\/a\u003e.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eSachets or capsules?\u003c\/h2\u003e\n  \u003cdiv class=\"cds-tw\"\u003e\n    \u003ctable class=\"cds-t\"\u003e\n      \u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003cth\u003eCFU\u003c\/th\u003e\n\u003cth\u003eTypical use\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n      \u003ctbody\u003e\n        \u003ctr\u003e\n\u003ctd\u003e\n\u003cstrong\u003e450B Sachets\u003c\/strong\u003e (this product)\u003c\/td\u003e\n\u003ctd\u003e450 billion \/ sachet\u003c\/td\u003e\n\u003ctd\u003eHigh-potency daily use; mix into a cool drink, yogurt or juice\u003c\/td\u003e\n\u003c\/tr\u003e\n        \u003ctr\u003e\n\u003ctd\u003e112B Capsules\u003c\/td\u003e\n\u003ctd\u003e112 billion \/ capsule\u003c\/td\u003e\n\u003ctd\u003eConvenient daily maintenance in capsule form\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003c\/tbody\u003e\n    \u003c\/table\u003e\n  \u003c\/div\u003e\n  \u003cp class=\"cds-note\"\u003eBoth formats contain the De Simone Formulation. The choice is potency preference and convenience. Buying for a month or more? The \u003ca href=\"https:\/\/probiotic.ie\/products\/cds22-formula-probiotic-450-billion-36-sachets\" target=\"_blank\" rel=\"noopener\"\u003e36-sachet pack\u003c\/a\u003e qualifies for free tracked Irish delivery over €75.\u003c\/p\u003e\n\n  \u003ch2\u003eHow we handle a refrigerated probiotic in Ireland\u003c\/h2\u003e\n  \u003cp\u003eA common question: will a refrigerated product survive delivery? CDS22-formula is \u003cstrong\u003eshelf-stable at room temperature (up to 25°C) for up to 7 days\u003c\/strong\u003e, per the manufacturer's storage leaflet, so a normal tracked Irish delivery is comfortably inside that window.\u003c\/p\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eStored refrigerated at +2–8°C\u003c\/strong\u003e in our temperature-controlled facility in Dublin, from receipt to dispatch.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eTracked delivery across Ireland\u003c\/strong\u003e, free on orders over €75.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eNo Friday dispatch\u003c\/strong\u003e, so nothing sits in a depot over the weekend.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eRefrigerate on arrival\u003c\/strong\u003e to maintain the live count through to the best-before date.\u003c\/li\u003e\n  \u003c\/ul\u003e\n  \u003cp class=\"cds-links\"\u003e\u003ca href=\"https:\/\/probiotic.ie\/pages\/delivery-information\" target=\"_blank\" rel=\"noopener\"\u003eFull delivery and storage information\u003c\/a\u003e\u003c\/p\u003e\n\n  \u003ch2\u003eWhy buy from Probiotic.ie\u003c\/h2\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eSole exclusive distributor\u003c\/strong\u003e of CDS22-formula for Ireland and the United Kingdom, appointed under written agreement with the manufacturer, EOS2021 S.r.l. Selecting Ireland on cds22.com directs customers here.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eRefrigerated storage from receipt to dispatch\u003c\/strong\u003e at our temperature-controlled Dublin facility, so the live count on the label is the count you receive.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eIrish-owned specialist since 2019\u003c\/strong\u003e, with real human support.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch2\u003eProduct details\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eFood supplement\u003c\/strong\u003e with 450 billion live cultures per sachet. \u003cstrong\u003eFormat:\u003c\/strong\u003e 12 sachets of 4.4g, 18-month shelf life from manufacture when stored refrigerated. \u003cstrong\u003eManufacturer:\u003c\/strong\u003e EOS2021 S.r.l. \u003cstrong\u003eGTIN\/EAN:\u003c\/strong\u003e 8055039380144.\u003c\/p\u003e\n\n  \u003ch3\u003eIngredients\u003c\/h3\u003e\n  \u003cp\u003eMaltose, mixture of lactic ferments (\u003cem\u003eStreptococcus thermophilus\u003c\/em\u003e NCIMB 30438, \u003cem\u003eBifidobacterium breve\u003c\/em\u003e NCIMB 30441, \u003cem\u003eBifidobacterium animalis\u003c\/em\u003e subsp. \u003cem\u003elactis\u003c\/em\u003e NCIMB 30435, \u003cem\u003eBifidobacterium animalis\u003c\/em\u003e subsp. \u003cem\u003elactis\u003c\/em\u003e NCIMB 30436, \u003cem\u003eLactobacillus acidophilus\u003c\/em\u003e NCIMB 30442, \u003cem\u003eLactobacillus plantarum\u003c\/em\u003e NCIMB 30437, \u003cem\u003eLactobacillus paracasei\u003c\/em\u003e NCIMB 30439, \u003cem\u003eLactobacillus helveticus\u003c\/em\u003e NCIMB 30440).\u003c\/p\u003e\n  \u003cp class=\"cds-note\"\u003eGluten-free. No preservatives or synthetic sweeteners. The live cell count refers to the product correctly stored in intact packaging at refrigerated temperature (+2–8°C) until the best-before date. Product composition and specifications can change — always check the current pack label before use.\u003c\/p\u003e\n\n  \u003ch3\u003eHow to use\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eAdults and children 7+:\u003c\/strong\u003e 1–2 sachets per day.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eChildren 3–6 years:\u003c\/strong\u003e up to ½ sachet per day.\u003c\/li\u003e\n    \u003cli\u003eOpen and mix into a cool, non-fizzy drink, yogurt or fruit juice; consume immediately. Do not add to hot liquids.\u003c\/li\u003e\n    \u003cli\u003eDo not exceed the recommended daily dose.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch3\u003eStorage\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003eStore in the refrigerator (+2–8°C) to maintain the live cultures until the best-before date.\u003c\/li\u003e\n    \u003cli\u003eCan be kept at room temperature (up to 25°C) for up to one week.\u003c\/li\u003e\n    \u003cli\u003eAvoid temperatures above 25°C. Do not freeze.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003cdiv class=\"cds-amber\"\u003e\n    \u003cdiv class=\"lbl\"\u003eUse in pregnancy \u0026amp; with antibiotics\u003c\/div\u003e\n    \u003cp style=\"margin:0;\"\u003eIf you are pregnant, breastfeeding, taking medication or under medical supervision, consult your doctor or pharmacist before use. CDS22-formula can be taken alongside antibiotics; taking it a few hours apart from the antibiotic dose is commonly advised. Anyone immunocompromised or seriously unwell should speak to a doctor first. For a young child, check with your GP or public health nurse before use.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv class=\"cds-box\"\u003e\n    \u003cp style=\"margin:0;\" class=\"cds-note\"\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e CDS22-formula is a food supplement, not a medicine. It is not intended to diagnose, treat, cure or prevent any disease or health condition. No authorised EU or Irish health claim is made for CDS22-formula or its bacterial strains on this page. The information here is for general information only and does not replace advice from a doctor, pharmacist or other qualified health professional. Food supplements in Ireland are regulated by the FSAI; for health information the HSE is the appropriate reference. Probiotic.ie is an independent company, operated by TenX Tech Ltd, and is not affiliated with, endorsed by, sponsored by or connected to any other probiotic manufacturer, brand owner or trademark holder.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003c!-- FAQ (matches schema below) --\u003e\n  \u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n  \u003cdiv class=\"cds-faq\"\u003e\n    \u003ch3\u003eWhat is CDS22-formula?\u003c\/h3\u003e\n    \u003cp\u003eCDS22-formula is the original 8-strain De Simone Formulation, a live bacteria food supplement developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Each sachet provides 450 billion live cultures (CFU) across eight strains, each identified on the Irish label by its NCIMB deposit code. It is sold in Ireland as a food supplement, not a medicine.\u003c\/p\u003e\n\n    \u003ch3\u003eHow many strains and how much CFU does CDS22-formula contain?\u003c\/h3\u003e\n    \u003cp\u003eEach sachet contains 8 bacterial strains delivering 450 billion live cultures (CFU): \u003cem\u003eStreptococcus thermophilus\u003c\/em\u003e NCIMB 30438 (226 billion), \u003cem\u003eBifidobacterium breve\u003c\/em\u003e NCIMB 30441 (24 billion), \u003cem\u003eBifidobacterium animalis\u003c\/em\u003e subsp. \u003cem\u003elactis\u003c\/em\u003e NCIMB 30435 (24 billion), \u003cem\u003eBifidobacterium animalis\u003c\/em\u003e subsp. \u003cem\u003elactis\u003c\/em\u003e NCIMB 30436 (24 billion), \u003cem\u003eLactobacillus acidophilus\u003c\/em\u003e NCIMB 30442 (38 billion), \u003cem\u003eLactobacillus plantarum\u003c\/em\u003e NCIMB 30437 (38 billion), \u003cem\u003eLactobacillus paracasei\u003c\/em\u003e NCIMB 30439 (38 billion), and \u003cem\u003eLactobacillus helveticus\u003c\/em\u003e NCIMB 30440 (38 billion). The capsule format delivers 112 billion CFU per capsule.\u003c\/p\u003e\n\n    \u003ch3\u003eDoes CDS22-formula need to be refrigerated?\u003c\/h3\u003e\n    \u003cp\u003eYes. CDS22-formula is a refrigerated product and should be stored at +2–8°C to maintain the live cultures, with an 18-month shelf life from manufacture when kept refrigerated. It can be kept at room temperature (up to 25°C) for up to one week. Probiotic.ie stores it refrigerated at a temperature-controlled facility in Dublin and dispatches on a tracked service across Ireland.\u003c\/p\u003e\n\n    \u003ch3\u003eWill CDS22-formula still be good when it arrives?\u003c\/h3\u003e\n    \u003cp\u003eYes. Per the manufacturer's storage leaflet, CDS22-formula is shelf-stable at room temperature up to 25°C for up to seven days, which comfortably covers a tracked Irish delivery. Probiotic.ie holds stock refrigerated in Dublin and does not dispatch on Fridays, so orders do not sit in a depot over the weekend. Refrigerate the product on arrival.\u003c\/p\u003e\n\n    \u003ch3\u003eIs CDS22-formula a medicine, and is it legal in Ireland?\u003c\/h3\u003e\n    \u003cp\u003eCDS22-formula is sold legally in Ireland as a food supplement under FSAI guidelines. It is not a medicine, it is not authorised by the HPRA, and it is not intended to diagnose, treat, cure or prevent any disease. No prescription is required.\u003c\/p\u003e\n\n    \u003ch3\u003eHow do I take CDS22-formula?\u003c\/h3\u003e\n    \u003cp\u003eAdults and children aged 7+ take 1–2 sachets per day; children aged 3–6 take up to ½ sachet per day. Mix the contents into a cool, non-fizzy drink, yogurt or fruit juice and consume immediately. Do not add to hot liquids. Do not exceed the recommended daily dose.\u003c\/p\u003e\n\n    \u003ch3\u003eWho is the authorised Irish distributor of CDS22-formula?\u003c\/h3\u003e\n    \u003cp\u003eProbiotic.ie is the sole exclusive distributor of CDS22-formula for Ireland and the United Kingdom, appointed under written agreement with the manufacturer, EOS2021 S.r.l. Selecting Ireland on the manufacturer's website, cds22.com, directs customers to Probiotic.ie. Probiotic.ie is an independent company and is not connected to any other probiotic manufacturer or brand owner.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cp class=\"cds-links\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0059\/3484\/1920\/files\/CDS22-FORMULA_450B_Patients_Sheet.pdf?v=1736860719\" target=\"_blank\" rel=\"noopener\"\u003eDownload the Patient Information Sheet\u003c\/a\u003e · \u003ca href=\"https:\/\/probiotic.ie\/collections\/cds22-formula-powerful-probiotics\" target=\"_blank\" rel=\"noopener\"\u003eSee the full CDS22-formula range\u003c\/a\u003e\u003c\/p\u003e\n\n\u003c\/div\u003e\n\n\u003c!-- FAQPage schema — matches the visible FAQ above verbatim.\n     Shopify auto-generates Product schema; do NOT add Product schema here. --\u003e\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is CDS22-formula?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"CDS22-formula is the original 8-strain De Simone Formulation, a live bacteria food supplement developed by Professor Claudio De Simone and manufactured by EOS2021 S.r.l. Each sachet provides 450 billion live cultures (CFU) across eight strains, each identified on the Irish label by its NCIMB deposit code. It is sold in Ireland as a food supplement, not a medicine.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How many strains and how much CFU does CDS22-formula contain?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Each sachet contains 8 bacterial strains delivering 450 billion live cultures (CFU): Streptococcus thermophilus NCIMB 30438 (226 billion), Bifidobacterium breve NCIMB 30441 (24 billion), Bifidobacterium animalis subsp. lactis NCIMB 30435 (24 billion), Bifidobacterium animalis subsp. lactis NCIMB 30436 (24 billion), Lactobacillus acidophilus NCIMB 30442 (38 billion), Lactobacillus plantarum NCIMB 30437 (38 billion), Lactobacillus paracasei NCIMB 30439 (38 billion), and Lactobacillus helveticus NCIMB 30440 (38 billion). The capsule format delivers 112 billion CFU per capsule.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Does CDS22-formula need to be refrigerated?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes. CDS22-formula is a refrigerated product and should be stored at +2 to +8°C to maintain the live cultures, with an 18-month shelf life from manufacture when kept refrigerated. It can be kept at room temperature (up to 25°C) for up to one week. Probiotic.ie stores it refrigerated at a temperature-controlled facility in Dublin and dispatches on a tracked service across Ireland.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Will CDS22-formula still be good when it arrives?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes. Per the manufacturer's storage leaflet, CDS22-formula is shelf-stable at room temperature up to 25°C for up to seven days, which comfortably covers a tracked Irish delivery. Probiotic.ie holds stock refrigerated in Dublin and does not dispatch on Fridays, so orders do not sit in a depot over the weekend. Refrigerate the product on arrival.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is CDS22-formula a medicine, and is it legal in Ireland?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"CDS22-formula is sold legally in Ireland as a food supplement under FSAI guidelines. It is not a medicine, it is not authorised by the HPRA, and it is not intended to diagnose, treat, cure or prevent any disease. No prescription is required.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How do I take CDS22-formula?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Adults and children aged 7 and over take 1 to 2 sachets per day; children aged 3 to 6 take up to half a sachet per day. Mix the contents into a cool, non-fizzy drink, yogurt or fruit juice and consume immediately. Do not add to hot liquids. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who is the authorised Irish distributor of CDS22-formula?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Probiotic.ie is the sole exclusive distributor of CDS22-formula for Ireland and the United Kingdom, appointed under written agreement with the manufacturer, EOS2021 S.r.l. Selecting Ireland on the manufacturer's website, cds22.com, directs customers to Probiotic.ie. Probiotic.ie is an independent company and is not connected to any other probiotic manufacturer or brand owner.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"CDS22-formula","offers":[{"title":"Default Title","offer_id":49847786504522,"sku":"CDS22-12pk","price":25.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0059\/3484\/1920\/files\/CDS22-FormulaHQ_21ec170e-c531-423e-a341-7fc473b5a3b0.jpg?v=1741357710","url":"https:\/\/probiotic.ie\/products\/cds22-formula-probiotic-450-billion-12-sachets","provider":"Probiotic.ie","version":"1.0","type":"link"}