Zenflore by PrecisionBiotics - Reduced Fatigue/Improved Mental – 30 Capsules
Zenflore is the world’s first and only supplement harnessing the unique 1714-Serenitas® bacterial culture.
Zenflore, with the unique 1714-Serenitas culture and specially selected B vitamins, has been specially formulated to reduce fatigue and support mental performance (1,2). The 1714-Serenitas culture in Zenflore has been clinically studied in people with everyday stress (3)
What is Zenflore?
The special 1714-Serenitas culture in Zenflore was discovered and developed by PrecisionBiotics, in partnership with scientists and clinicians from one of the world’s leading centres of research on the microbiome and the gut-brain axis.
What is the Gut-Brain Axis?
The connection between our brain and our gut is already part of how we describe experiences - having a "gut-feeling" or nervous with "butterflies" in the gut. Scientists call this connection the gut-brain axis (5) - the two-way dialogue between the brain and the gut where information flows between the two organs.
A key physical link that relays the information between the gut and the brain is the vagus nerve.(7) This nerve relays information using molecules called neurotransmitters (chemical messengers). Approximately 80-90% of nerve fibres in the vagus nerve are going from the gut to the brain.(8)
Evidence shows that bacteria (also known as microbes) in the gut can act on the gut-brain axis and hence influence gut-brain communications.(6) The gut produces more than 90% of the serotonin found in the body (9) - this is a neurotransmitter that can affect mood and feelings of happiness and pleasure and research has shown that specific gut bacteria can impact its production in the gut (10).
The naturally occurring 1714-Serenitas culture is part of the family of bacteria given by mother to baby at birth(4). It is a 'friendly' bacteria that is naturally at home in the human gut. Zenflore food supplement is not a medicine and is not a substitute for any medication prescribed for you by your doctor. Do not discontinue any medication without consulting your doctor.
How to take Zenflore;
- Take one capsule every day. Zenflore can be taken with or without food, at any time of the day. Note: Fruit juices are generally acidic and acid can damage the 1714-Serenitas culture. We recommend taking Zenflore with water or milk.
- Does not require refrigeration.
- Zenflore acts immediately and begins to prime your gut where it is needed. During the first 2 weeks it will help reset your system.
- It is important to take Zenflore every day. To see the full effects of Zenflore can take approximately 4 weeks, depending on the individual gut.
If you have any questions at all about Zenflore, please post your questions in the below Q&A section and we will reply promptly to your query.
1. Pantothenic Acid: Contributes to normal mental performance; Biotin, Folate, Niacin, Thiamine, Vitamin B12, Vitamin B6: Contributes to normal psychological function
2. Folate, Niacin, Pantothenic Acid, Riboflavin, Vitamin B12, Vitamin B6: Contributes to the reduction of tiredness and fatigue; Biotin, Niacin, Pantothenic Acid, Riboflavin, Thiamine, Vitamin B12, Vitamin B6: Contributes to normal energy yielding metabolism.
3. Allen et al. (2016). Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Translational Psychiatry, 6(11), pp.e939-e939.
4. Turroni et al. 2012. Diversity of Bifidobacteria within the Infant Gut Microbiota.
5. Dinan, T. and Cryan, J. (2017). Brain–gut–microbiota axis - mood, metabolism and behaviour. Nature Reviews Gastroenterology & Hepatology, 14(2), pp.69-70.
6. Dinan, T. and Cryan, J. (2015). The impact of gut microbiota on brain and behaviour. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), pp.552-558.
7. Bonaz et al. (2018). The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Frontiers in Neuroscience, 12.
8. Ruffoli et al. (2011). The chemical neuroanatomy of vagus nerve stimulation. Journal of Chemical Neuroanatomy, 42(4), pp.288-296.
9. Gershon, M. and Tack, J. (2007). The Serotonin Signaling System: From Basic Understanding to Drug Development for Functional GI Disorders. Gastroenterology, 132(1), pp.397-414.
10. Kennedy et al. (2017). Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology, 112, pp.399-412.
11. Clemente et al. (2012). The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell, 148(6), pp.1258-1270.
12. Wang et al. (2019). Bifidobacterium longum 1714 Strain Modulates Brain Activity of Healthy Volunteers During Social Stress. American Journal of Gastroenterology 00:1–11.